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09-082025

Immunity | Daichao Xu’s Lab discovered that oxidized left-handed DNA, a new ligand of ZBP1, drives neuroinflammation in Alzheimer's disease

This study identified oxidized left-handed DNA as a new ligand for ZBP1, breaking the previous notion that ZBP1 mainly recognizes exogenous pathogen nucleic acids or unmodified endogenous nucleic acids, which also provided a new perspective on the immune mechanism of AD. Since ROS is widely present in various human diseases, this discovery also provides important insights for the mechanism research and treatment strategies of other ROS-related human diseases. RIPK1 inhibitors are in the clinical trial stage currently. This study provides a theoretical basis for their application in AD treatment. In the future, RIPK1 inhibitors combined with Aβ-targeted therapy may be a new strategy for AD patients.
08-262025

Molecular Cell | Yixiao Zhang’s Team Uncovers the Regulatory Mechanism of XPR1, a Key Protein in Brain Calcification

This work establishes two conceptual advances: The “key-to-locks” model, in which InsP8 sequentially removes restraints imposed by KIDINS220 and intrinsic elements of XPR1. The “knock–kiss–kick” model, describing a phosphate efflux mechanism distinct from classical transporter paradigms. These discoveries provide a molecular framework for understanding phosphate homeostasis and lay the foundation for exploring therapeutic interventions in XPR1-related diseases such as brain calcification and cancer.
08-062025

Zhu Zheng-Jiang’s research group and collaborators developed photocatalytic proximity labeling technology for organelle-selective lipid analysis

Researchers first innovatively developed a proximity labeling strategy for selective lipid analysis. Based on the structural characteristics of lipids, a photocatalytic proximity labeling probe was specifically designed and optimized for lipid reactivity. Organic dyes with organelle-specific localization were used as photocatalysts to activate the probe under blue light irradiation, generating reactive intermediates that selectively label lipids within specific organelles and yielding photocatalytically labeled (PL) lipids. Detection of PL-lipids was achieved through liquid chromatography–mass spectrometry (LC-MS)-based lipidomic analysis, without the need for organelle separation.
07-292025

Advanced Science | Zhang Yaoyang’s Team Develops DeepSecMS for In-Depth Selenoproteome Profiling

In summary, the newly developed DeepSecMS method represents a powerful tool for selenoprotein identification and holds great potential for discovering novel selenoproteins. This innovative approach signifies a substantial advancement in selenoproteomics, offering new tools into selenoprotein exploration and its potential roles in human health and disease. Moreover, this proxy training strategy may be extended to the analysis of other rare post-translational modifications, providing a scalable technical framework to advance trace proteomics research.
07-142025

Nature Communications | Liu Cong and Collaborators Discover That O-Glycopeptides Remodel Aβ Aggregation and Attenuate Its Neurotoxicity

This study reports that a tyrosine O-glycosylated peptide with a specific β-N-acetylgalactosamine (β-GalNAc) modification can co-assemble with Aβ42, accelerating the formation of novel amyloid fibril structures that reduce toxic oligomer accumulation and alleviate neurotoxicity. The team designed a series of O-glycosylated peptides based on the Aβ aggregation core fragment (Gly9–Ala21), incorporating diverse monosaccharide units and glycosidic linkages, to evaluate their effects on Aβ42 aggregation. Screening identified β-GalNAc–modified Aβ9–21 (4b) as a strong promoter of Aβ42 fibril formation, while reducing the build-up of toxic oligomers (Figure 1), indicating a shift toward low-toxicity aggregates.
06-262025

Cell Metabolism | Xu Daichao’s Team Identifies a Methionine Metabolism Sensor that Regulates Cell Death

In summary, this study identifies RIPK1 as a novel sensor for SAM abundance, capable of responding to methionine and SAM metabolic changes to control cell fate decisions. SAM deficiency contributes to the development of diseases related to cell death and inflammation. Given that RIPK1 inhibitors have shown promise in clinical trials for various inflammatory and degenerative diseases, this research suggests RIPK1 as a potential therapeutic target for human diseases associated with SAM dysregulation.
06-132025

PNAS | A New Mechanism of PARP12 in Regulating Cell Death and Antiviral Immunity

This work provides several important advances: (1) it identifies PARP12 as a novel regulator of cell death pathways, (2) elucidates a previously unknown mechanism of RIPK1/3 regulation through MARylation, and (3) reveals a molecular checkpoint that coordinates cell death and antiviral immune responses. These findings not only deepen our understanding of host-virus interactions but also suggest PARP12 as a potential therapeutic target for influenza and other viral infections.
04-112025

New Mechanism Found to regulate α-synuclein Spread in Parkinson’s Disease and Related Disorders

This study marks a significant shift in the field of neurodegenerative disease research. It underscores the importance of looking beyond the well-studied rigid fibril core to understand the complex biology of protein aggregation. The study not only deepens our understanding of neurodegenerative disease pathology but also paves the way for the development of more targeted interventions.

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News & Research

News & Research

Immunity | Daichao Xu’s Lab discovered that oxidized left-handed DNA, a new ligand of ZBP1, drives neuroinflammation in Alzheimer's disease

Molecular Cell | Yixiao Zhang’s Team Uncovers the Regulatory Mechanism of XPR1, a Key Protein in Brain Calcification

Zhu Zheng-Jiang’s research group and collaborators developed photocatalytic proximity labeling technology for organelle-selective lipid analysis

Advanced Science | Zhang Yaoyang’s Team Develops DeepSecMS for In-Depth Selenoproteome Profiling

Nature Communications | Liu Cong and Collaborators Discover That O-Glycopeptides Remodel Aβ Aggregation and Attenuate Its Neurotoxicity

Cell Metabolism | Xu Daichao’s Team Identifies a Methionine Metabolism Sensor that Regulates Cell Death

PNAS | A New Mechanism of PARP12 in Regulating Cell Death and Antiviral Immunity

New Mechanism Found to regulate α-synuclein Spread in Parkinson’s Disease and Related Disorders

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