2024-now, Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,China, Principal Investigator. 

2021-2024 University Hospital Heidelberg, Germany, Temporary Principal Investigator

2019-2021 Helmholtz Center Munich, Germany, Postdoctoral Researcher

2014-2019 Ludwig-Maximilians-University (LMU) Munich, Germany, Ph.D.

2010-2013 Lanzhou University, China, M.S.

2006-2010 Lanzhou University, China, B.S.

Dr. Chenchen Pan has long been devoted in the research of tissue clearing and imaging technologies. The current main research directions include developing and optimizing whole-body tissue clearing and imaging techniques; systematic study of pathologies caused by neurodegenerative diseases; study of the interactions between the nervous system and global cancer metastases.

1、Optimization and development of whole-body tissue clearing and imaging techniques

2、Study of systemic alterations caused by neurodegenerative diseases.

3、Study of the interactions between the nervous system and systemic cancer metastasis

1. Chenchen Pan*, Oliver Schoppe*, Arnaldo Parra-Damas*, Ruiyao Cai, Mihail Ivilinov Todorov, Gabor Gondi, Bettina von Neubeck, Nuray Bögürcü-Seidel, Sascha Seidel, Katia Sleiman, Christian Veltkamp, Benjamin Fo¨rstera, Hongcheng Mai, Zhouyi Rong, Omelyan Trompak, Alireza Ghasemigharagoz, Madita Alice Reimer, Angel M. Cuesta, Javier Coronel, Irmela Jeremias, Dieter Saur, Amparo Acker-Palmer, Till Acker, Boyan K. Garvalov, Bjoern Menze, Reinhard Zeidler, and Ali Ertürk. (2019). Deep learning reveals cancer metastasis and therapeutic antibody targeting in the entire body. Cell 179, 1661-1676 e1619. (Cover story)

https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3

2. Ruiyao Cai*, Chenchen Pan*, Alireza Ghasemigharagoz, Mihail Ivilinov Todorov, Benjamin Förstera, Shan Zhao, Harsharan S. Bhatia, Arnaldo Parra-Damas, Leander Mrowka, Delphine Theodorou, Markus Rempfler, Anna L. R. Xavier , Benjamin T. Kress, Corinne Benakis, Hanno Steinke, Sabine Liebscher, Ingo Bechmann, Arthur Liesz, Bjoern Menze, Martin Kerschensteiner , Maiken Nedergaard and Ali Ertürk. (2019). Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nature neuroscience 22, 317-327. (Cover story)

https://www.nature.com/articles/s41593-018-0301-3

3. Chenchen Pan*, Ruiyao Cai*, Francesca Paola Quacquarelli*, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, Paweł Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali Ertürk. (2016) Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nature methods 13, 859-867. (Cover story)

https://www.nature.com/articles/nmeth.3964

4. Chenchen Pan, Frank Winkler. (2022) Insights and opportunities at the crossroads of cancer and neuroscience. Nature Cell Biology 24 (10), 1454-1460.

https://www.nature.com/articles/s41556-022-00978-w

5. Ruiyao Cai*, Zeynep Ilgin Kolabas*, Chenchen Pan, Hongcheng Mai, Shan Zhao, Doris Kaltenecker, Fabian F. Voigt, Muge Molbay, Tzu-lun Ohn, Cécile Vincke, Mihail I. Todorov, Fritjof Helmchen, Jo A. Van Ginderachter, Ali Ertürk. (2023) Whole-mouse clearing and imaging at the cellular level with vDISCO. Nature Protocols 18, 1197–1242 (2023). (Cover story)

https://www.nature.com/articles/s41596-022-00788-2

6. Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahue De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, Maria de la Fuente-Fernández, Angel Luis Garcia-Villalon, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Ertürk, Charles A. LeDuc, Kamal Rahmouni, Miriam Granado, Tamas L. Horvath, Matthias H. Tschöp, Cristina García-Cáceres. (2021) Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metabolism 33 (6), 1155-1170. e10.

https://www.cell.com/action/showPdf?pii=S1550-4131%2821%2900173-X

7. Oliver Schoppe, Chenchen Pan, Javier Coronel, Hongcheng Mai, Zhouyi Rong, Mihail Ivilinov Todorov, Annemarie Müskes, Fernando Navarro, Hongwei Li, Ali Ertürk, Bjoern H. Menze. (2020) Deep learning-enabled multi-organ segmentation in whole-body mouse scans. Nature communications 11 (1), 1-14.

https://www.nature.com/articles/s41467-020-19449-7

8. Douglas S. Richardson, Webster Guan, Katsuhiko Matsumoto, Chenchen Pan, Kwanghun Chung, Ali Ertürk, Hiroki R. Ueda, Jeff W. Lichtman. (2021) Tissue clearing. Nature Reviews Methods Primers 1 (1), 1-24.

https://www.nature.com/articles/s43586-021-00080-9

9. Bettina von Neubeck*, Gabor Gondi*, Chiara Riganti , Chenchen Pan, Arnaldo Parra Damas, Hagen Scherb, Ali Ertürk, Reinhard Zeidler. (2018) An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. International Journal of Cancer 143, 2065-2075.

https://onlinelibrary.wiley.com/doi/10.1002/ijc.31607

10. Leo M Miyakoshi, Frederik F Stæger, Qianliang Li, Chenchen Pan, Lulu Xie, Hongyi Kang, Chiara Pavan, Juliana Dang, Qian Sun, Ali Ertürk, Maiken Nedergaard. (2023) The state of brain activity modulates cerebrospinal fluid transport. Progress in Neurobiology 229, 102512.

https://www.sciencedirect.com/science/article/abs/pii/S0301008223001132?via%3Dihub

11. Katharina Schregel, Lennart Heinz, Jessica Hunger, Chenchen Pan, Julia Bode, Manuel Fischer, Volker Sturm, Varun Venkataramani, Kianush Karimian-Jazi, Dennis A Agardy, Yannik Streibel, Roland Zerelles, Wolfgang Wick, Sabine Heiland, Theresa Bunse, Björn Tews, Michael Platten, Frank Winkler, Martin Bendszus, Michael O Breckwoldt. (2023) A Cellular Ground Truth to Develop MRI Signatures in Glioma Models by Correlative Light Sheet Microscopy and Atlas-Based Coregistration. The Journal of Neuroscience 43, 5574.

https://www.jneurosci.org/content/43/30/5574/tab-article-info

* co-first authors