• Principal Investigator: 10/2024-present, Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China

• Postdoctoral researcher: 02/2020-09/2024, UT Southwestern Medical Center, U.S.A

• Scientific Researcher: 06/2019-12/2019, Ludwig Maximilian University of Munich (LMU), Germnay

• Ph.D.:10/2014-05/2019, Ludwig Maximilian University of Munich (LMU), Germany

• MSc.: 09/2011-07/2014, Shandong Agricultural University (07/2012-07/2014, visiting MSc. at The Institute of Genetic and Developmental Biology, Chinese Academy of Sciences)

• B.Sc.: 09/2007-07/2011, Shandong Agricultural University

Lipotoxicity, pan-stresses (i.e. non-genotoxicity and genotoxicity), and axon regeneration defects play important roles in contributing animals’ health issues and aging process. My previous studies have shown that CED-3/caspase has a significant impact on pan-stress response and lipid metabolism programming. However, detailed mechanisms of CED-3/caspase in regulating those physiological processes are unclear. By majorly using C.elegans as a model organism, I am trying to study and answer the following questions: 1.Role of CED-3/caspase in regulation of lipotoxicity and aging process 2.Uncover mechanism of CED-3/caspase in mediating Pan-stress (non-genotoxicity and genotoxicity) responsiveness. 3.Unravel CED-3/caspase role in motor neuron axon regeneration. We also aim to unravel other key regulators, which are in parallel to CED-3/caspase, in the above physiological processes. Furthermore, conserved physiological roles or regulation mechanisms by CED-3/caspase will be further investigated into mammalian cells.

•Hai Wei, Yi M. Weaver, Benjamin P. Weaver2024 Xeroderma pigmentosum protein XPD controls caspase- mediated stress responses. Nature Communications PMID: 39472562, DOI:https://doi.org/10.1038/ s41467-024-53755-8

•Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinisand Benjamin P. Weaver2024 Proteolytic Activation of Fatty Acid Synthase Signals Pan-Stress Resolution. Nature Metabolism PMID: 38167727, DOI: 10.1038/s42255-023-00939-z (Cover Article, Highlighted and collected by Nature Metabolism)

•Aditya Sethi#, Hai Wei#, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin and Barbara Conradt 2022 A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLOS Biology PMID: 36201522, DOI: 10.1371/journal.pbio.3001786 (#equal contribution)

•Hai Wei, Lambie EJ, Oso´rio DS, Carvalho AX, Conradt B. 2020 PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLOS Genetics PMID: 32946434, DOI: 10.1371/journal.pgen.1008912

•W. Deng, Jack A. Bates, Hai Wei, Michael D. Bartoschek, Barbara Conradt & Heinrich Leonhardt, 2020 Tunable light and drug induced depletion of target proteins. Nature Communications PMID: 31949141, DOI:10.1038/s41467-019 -14160-8

•Mishra N., Hai Wei, and B. Conradt, 2018 Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die. GENETICS PMID: 30194072, DOI:10.1534/genetics. 118.301500

•Hai Wei#, Bo Yan#, J. Gagneur, and B. Conradt, 2017 Caenorhabditis elegans ces-1 Snail represses pig-1 MELK expression to control asymmetric cell division. GENETICS PMID: 28652378, DOI:10.1534/genetics.117.202754 (#equal contribution)

•Qingliang Li#, Hai Wei#, Lijing Liu, Xiaoyuan Yang, Xiansheng Zhang, Qi Xie, 2017 Unfolded protein response activation compensates endoplasmic reticulum-associated degradation deficiency in Arabidopsis. Journal of Integrative Plant Biology PMID: 28418178, DOI: 10.1111/jipb.12544 (#equal contribution)