The Zhang Lab is interested in the molecular and cellular mechanisms of aging. Leveraging C. elegans, mammalian tissue cultures, and mouse models, we bridge discoveries from cells to organisms, and ultimately to human health. We take advantage of cutting-edge genetics to identify novel genes that regulate cellular homeostasis, cell biology and biochemistry approaches to decode their molecular functions, immunology and physiology experimental systems to assess the physiological impact of our findings on organismal health. Through our research, we seek not only to understand the fundamental biology of aging, but also to translate these discoveries into strategies that promote healthy longevity in humans.
Our previous work revealed that cellular homeostasis is regulated by diverse signals from the microenvironment, i.e. the extracellular matrix (ECM), including fibrous components, cytokines and growth factors, and circulating metabolites. These signals are integrated through crosstalk between the ECM and intracellular organelles – such as nuclei, mitochondria, lysosomes – to regulate cellular function. Currently, the Zhang Lab focuses on:
1) Defining the molecular network of ECM-to-intracellular organelle communication;
2) Exploring how ECM remodelling influences tissue function and aging.
Dr. Zhang’s academic journey began in China (BSc, Peking University), continued in the United Kingdom (DPhil, University of Oxford, with Dr. Katja Simon), and the United States (Postdoc, UC Berkeley, with Dr. Andrew Dillin). Inspired by this international experience, the Zhang lab is committed to fostering a collaborative and inclusive lab environment while maintaining a global scientific network. Established in 2025, we look forward to closely working with colleagues across academic disciplines and geological regions to advance the exciting aging research field together!
For inquiries about collaborations, internships, studentships, or postdoc opportunities, please contact hanlin.zhang@sioc.ac.cn .