2011-2015:  Postdoc,JHU

2010:        Postdoc,UMD

2004-2009:  Ph.D. in Neuroscience,UMD

1999-2003:  B.S. in Biological Science,Tsinghua Universitiy

Dr. Kaiwen He is currently a Principal investigator of the Interdisciplinary Research Center on Biology and Chemistry (IRCBC),Chinese Academy of Science. She graduated from Tsinghua University in 2003 with a bachelor degree in Biological Science,and then received her Ph.D in Neuroscience from the University of Maryland College Park in 2009 by studying the regulation of AMPARs and synaptic plasticity. She joined IRCBC after finishing her postdoctoral training in Johns Hopkins University in 2015.

Dr. He’s laboratory is interested in understanding how neural and brain function is regulated in the normal brain,and how they are dysregulated in the diseased brain. They are in particularly curious about the role of sleep and its correlation with our brain fitness,and the neuronal dysfunction associated with the early stage of neurodegeneration.

Recent publications:

1. Cao Z, Min X, Xie X, Huang M, Liu Y, Sun W, Xu G, He M, He K^#, Li Y, Yuan J^#. RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT. PNAS. 2024 Feb 6;121(6): e2320383121. doi: 10.1073/pnas.2320383121. Epub 2024 Jan 30. PubMed PMID: 38289948.

2. Guo R., Liu J., Min X., Zeng W., Shan B., Zhang M., He Z., Zhang Y., He K., Yuan J., Xu D.^#. Reduction of DHHC5-mediated Beclin 1 S-palmitoylation underlies autophagy decline in aging. Nat Struct Mol Biol. 2024 Jan 4; doi: 10.1038/s41594-023-01163-9. PubMed PMID: 38177673.

3. Min X, Wang JY, Zong FJ, Zhao J, Liu N, He KW^#. miR-34a regulates silent synapse and synaptic plasticity in mature hippocampus. Prog Neurobiol. 2023 Jan 13;222:102404. doi: 10.1016/j.pneurobio.2023.102404.

4. Zong FJ, Min X, Zhang Y, Li YK, Zhang XT, Liu Y, He KW^#. Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons. EMBO J. 2023 Feb 1;42(3):e111304. doi: 10.15252/embj.2022111304. Epub 2022 Dec 7. PMID: 36477886; PMCID: PMC9890233.

5. Wang JY, Ma GM, Tang XQ, Shi QL, Yu MC, Lou MM, He KW^#, Wang WY^#. Brain region-specific synaptic function of FUS underlies the FTLD-linked behavioural disinhibition. Brain. 2023 May 2;146(5):2107-2119. doi: 10.1093/brain/awac411. PubMed PMID: 36345573

6. T Li, Y Yin, Z Zhou, J Qiu, W Liu, X Zhang, K He, Y Cai, ZJ Zhu^# (2021) Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain, Nature Communications 12 (1), 1-13

7. Long H*, Zheng W*, Liu Y, Sun Y, Zhao K, Liu Z, Xia W, Lv S, Liu Z, Li D, He KW^#, Liu C^# (2021) Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding. PNAS, 118(20):e2012435118. doi: 10.1073/pnas.2012435118. PMID: 33972418.

8. M Bridi*, F-J Zong*, X Min N Luo, T Tran, J Qiu, D Severin, X-T Zhang, G Wang, Z-J Zhu, K-W He^#, A Kirkwood^# (2020) Daily Oscillations in the Excitation-Inhibition Balance in Visual Cortical Circuits, Neuron, 105(4):621-629.e4. doi: 10.1016/j.neuron.2019.11.011

9. Bridi MCD, de Pasquale R, Lantz CL, Gu Y, Borrell A, Choi SY, He K, Tran T, Hong SZ, Dykman A, Lee HK, Quinlan EM, Kirkwood A^# (2018) Two distinct mechanisms for experience-dependent homeostasis. Nat Neurosci. 21(6):843-850

10. He K, Huertas M, Hong S, Tie X, Hell J.W, Shouval H, Kirkwood A^# (2015) Distinct Eligibility Traces for LTP and LTD in Cortical Synapses. Neuron, 88(3): 528-38