2023-Current,PI,IRCBC,Shanghai, China

2018-2023,Postdoc,UC SanDiego,California, USA

2017-2018,Postdoc,Chinese Academy of Sciences, Shanghai, China

2010-2017,Ph.D. ,Chinese Academy of Sciences, Shanghai, China

2006-2010,B.S,Zhejiang university of technology, Zhejiang, China

The research of ZhouLab focuses on the dynamic process of single-cell aging and the design of biocircuits for cellular automation. Our goal is to develop cellular robotics by leveraging the design principles of cellular network topology to address challenges in disease treatment and biotechnological applications.

• Zhou Z, Liu YT, Feng YS, Klepin S, Tsimring LS, Pillus L, Hasty J, Hao N. (2023) Engineering longevity – design of a synthetic gene oscillator to slow cellular aging. Science. 2023;380,376-381. PMID:37104589

• Liu Y*, Zhou Z*, Wu SL, Klepin S, Tsimring LS, Pillus L, Hasty J, and Hao N. Enhanced cellular longevity arising from environmental fluctuations. bioRxiv. 2023 *equal contribution

• Paxman J*, Zhou Z*, O'Laughlin R, Liu Y, Li Y, Tian W, Su H, Jiang Y, Holness SE, Stasiowski E, Tsimring LS, Pillus L, Hasty J, Hao N. (2022) Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis. eLife. doi: 10.7554/eLife.75978. PMID: 36194205 *equal contribution

• Zhou Z*, Liu YT*, Gong T, Ma L, Hu YN, Li HT, Cai C, Zhang LL, Wei G, Zhou JQ. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife. doi: 10.7554 PMID: 29027902 *equal contribution

• Gong T, Liu YT, Zhou Z, Zhang LL, Gu X, Wen Y, Zhong WL, Xu GL and Zhou JQ. (2018) Combinatorial K4me0-K36me3 marks on sister histone H3s are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation. J Genet Genomics. 47(2):105-114 PMID: 32173286

• Lv FJ, Zhang TL, Zhou Z, Gao SX, Wong CL, Zhou JQ and Ding JP. (2015) Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell discov. 1:15037. PMID: 27462434

• Li HT, Gong T, Zhou Z, Liu YT, Cao X, Yang H, Chen CD, Zhou JQ. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochem J. 467(3):507-15. PMID: 25715670

• Qian H, Chen W, Li J, Wang J, Zhou Z, Liu W, Fu Z. (2009) The effect of exogenous nitric oxide on alleviating herbicide damage in Chlorella vulgaris. Aquat Toxicol. 17;92 (4):250-7. PubMed PMID: 19297032