EDUCATION

2012   Ph.D.Neurobiology   Institute of Neuroscience, Chinese Academy of Sciences

                                             Shanghai, China 

                                             Mentor: Dr. Yizheng Wang, Academician of Chinese Academy 

                                             of Sciences

2005   B.S.Biotechnology    Wuhan University

                                             Hubei, China

RESEARCH EXPERIENCE

2019-            Principal Investigator, Interdisciplinary Research Center on Biology and Chemistry, SIOC, CAS

2018-2019      Research Associate, University of Pennsylvania, USA

2013-2018      Postdoctoral researcher, University of Pennsylvania, USA

              Advisors: Dr. Virginia M.-Y. Lee and John Q. Trojanowski, Academician of 

              American National Academy of Medicine

2012             Assistant Investigator, Institute of Neuroscience, CAS, China

The research of Dr. Zhuohao He focuses on underlying mechanisms about neuropathogenesis in neurodegenerative diseases, including Alzheimer’s disease (AD) and Frontotemporal lobar degeneration (FTLD). To untangle the questions, he has been developing new disease research animal models with endogenous physiological protein transformed into pathologies as exist in patients’ brains. His group is aiming to using such more disease-relevant models to study the pathogenesis mechanisms underlying neurodegenerative diseases, and identify the biomarkers and targets for early disease diagnoses and interventions.

Dr. He has been devoted to the research about pathological tau transmission in AD and FTLD. His studies have provided insights on three major issues in AD-related tau transmission process, including the initial seed formation (Science Translational Medicine, 2023, PMID: 37703352), the seed templating and amplification (Nature Communication, 2020, PMID: 31911587), as well as the subsequent seed spreading (Nature Medicine, 2018, PMID: 29200205).

Dr He earned his B.Sc. in Biotechnology from Wuhan University (2005), followed by his Ph.D. in Neurobiology under the mentorship of Dr. Yizheng Wang from Institute of Neuroscience, Chinese Academy of Sciences (CAS) (2012). Then he conducted his postdoctoral research with Drs. Virginia Lee and John Trojanowski at University of Pennsylvania. Since 2020, Dr. He has been leading an independent research group at Interdisciplinary Research Center on Biology and Chemistry (IRCBC), CAS to pursue his continuous interest in neurodegenerative disease research.

PUBLICATIONS (Total Google Scholar Citations >2000)

Research articles:

16. Guo R.; Liu J.; Min X.; Zeng W.; Shan B.; Zhang M.; He Z.; Zhang Y.; He K.; Yuan J.; Xu D.*. Reduction of DHHC5-mediated Beclin 1 S-palmitoylation underlies autophagy decline in aging. Nat. Struct. Mol. Biol. 2024, PMID: 38177673.

15. Zhao X.#; Zeng W.#; Xu H.#; Sun Z.; Hu Y.; Peng B.; McBride, J.D.; Duan J.; Zhang B.; Kim S.J.; Zoll B.; Saito T.; Sasaguri H.; Saido T.C.; Ballatore C.; Yao H.; Wang Z.; Trojanowski J.Q.; Brunden K.R.; Lee V.M.Y.*; He Z.*. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Sci. Transl. Med. 2023, PMID: 37703352.

14. Zhang S.;Zhu Y.; Lu J.; Liu Z.; Lobato A.G.; Zeng W.; Liu J.; Qiang J.; Zeng S.; Zhang Y.; Liu C.; Liu J.; He Z.; Zhai R.G.; Li D.*. Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology. ELife, 2022, PMID: 36048712.

13. Xu G.; Li Y.; Zhang S.; Peng H.; Wang Y.; Li D.; Jin T.; He Z.; Tong Y.; Qi C.; Wu G.; Dong K.; Gou J.; Liu Y.; Xiao T.; Qu J.; Li L.; Liu L.; Zhao P.; Zhang Z.; Yuan J. *. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. Cell Research, 2021, PMID: 34663909.

12. Darwich, N. F.; Phan, J. M.; Kim, B.; Suh, E.; Papatriantafyllou, J. D.; Changolkar, L.; Nguyen, A. T.; O'Rourke, C. M.; He, Z.; Porta, S.; Gibbons, G. S.; Luk, K. C.; Papageorgiou, S. G.; Grossman, M.; Massimo, L.; Irwin, D. J.; McMillan, C. T.; Nasrallah, I. M.; Toro, C.; Aguirre, G. K.; Van Deerlin, V. M.; Lee, E. B.*, Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science 2020, PMID: 33004675.

11. Xu, D.; Zhao, H.; Jin, M.; Zhu, H.; Shan, B.; Geng, J.; Dziedzic, S. A.; Amin, P.; Mifflin, L.; Naito, M. G.; Najafov, A.; Xing, J.; Yan, L.; Liu, J.; Qin, Y.; Hu, X.; Wang, H.; Zhang, M.; Manuel, V. J.; Tan, L.; He, Z.; Sun, Z. J.; Lee, V. M. Y.; Wagner, G.; Yuan, J.*, Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature 2020, PMID: 32968279.

10. Weitzman, S. A.; Narasimhan, S.; He, Z.; Changolkar, L.; McBride, J. D.; Zhang, B.; Schellenberg, G. D.; Trojanowski, J. Q.; Lee, V. M. Y.*, Insoluble tau from human FTDP-17 cases exhibit unique transmission properties in vivo. J Neuropathol Exp Neurol 2020, PMID: 32838419.

9. He, Z.*; McBride, J. D.; Xu, H.; Changolkar, L.; Kim, S. J.; Zhang, B.; Narasimhan, S.; Gibbons, G. S.; Guo, J. L.; Kozak, M.; Schellenberg, G. D.; Trojanowski, J. Q.; Lee, V. M.*, Transmission of tauopathy strains is independent of their isoform composition. Nat Commun 2020, PMID: 31911587.

8. He, Z.; Guo, J. L.; McBride, J. D.; Narasimhan, S.; Kim, H.; Changolkar, L.; Zhang, B.; Gathagan, R. J.; Yue, C.; Dengler, C.; Stieber, A.; Nitla, M.; Coulter, D. A.; Abel, T.; Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.*, Amyloid-beta plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nat Med 2018, PMID: 29200205.

7. Narasimhan, S.; Guo, J. L.; Changolkar, L.; Stieber, A.; McBride, J. D.; Silva, L. V.; He, Z.; Zhang, B.; Gathagan, R. J.; Trojanowski, J. Q.; Lee, V. M. Y.*, Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. J Neurosci 2017, PMID: 29054878.

6. Guo, J. L.; Narasimhan, S.; Changolkar, L.; He, Z.; Stieber, A.; Zhang, B.; Gathagan, R. J.; Iba, M.; McBride, J. D.; Trojanowski, J. Q.; Lee, V. M.*, Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. J Exp Med 2016, PMID: 27810929.

5. Wang, J.; Lu, R.; Yang, J.; Li, H.; He, Z.; Jing, N.; Wang, X.; Wang, Y.*, TRPC6 specifically interacts with APP to inhibit its cleavage by gamma-secretase and reduce Abeta production. Nat Commun 2015, PMID: 26581893.

4. He, Z.; Jia, C.; Feng, S.; Zhou, K.; Tai, Y.; Bai, X.; Wang, Y.*, TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIalpha in rat hippocampal neurons. J Neurosci 2012, PMID: 22764246.

3. Ding, X.#; He, Z.#; Zhou, K.#; Cheng, J.; Yao, H.; Lu, D.; Cai, R.; Jin, Y.; Dong, B.; Xu, Y.; Wang, Y.*, Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J Natl Cancer Inst 2010, PMID: 20554944.

2. Shi, Y.#; Ding, X.#; He, Z.#; Zhou, K. C.; Wang, Q.; Wang, Y. Z.*, Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut 2009, PMID: 1965162.

1. Tai, Y.; Feng, S.; Ge, R.; Du, W.; Zhang, X.; He, Z.; Wang, Y.*, TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway. J Cell Sci 2008, PMID: 18559891.

Review articles:

5. Zhang T.; Cong L.; Chen B.; He Z.; Li G.; Qin Q. Editorial: Multimodal interventions in Alzheimer's disease: from basic research to clinical practice. Front Neurol 2023, PMID: 37928148

4. Han, Y.; He, Z.*, Concomitant protein pathogenesis in Parkinson's disease and perspective mechanisms. Front Aging Neurosci 2023, PMID: 37181621.

3. He, Z.*, TRPC Channel Downstream Signaling Cascades. Adv Exp Med Biol 2017, PMID: 28508310.

2. Feng, S.; He, Z.; Li, H.; Wang, Y.*, Ca(2+) signaling initiated by canonical transient receptor potential channels in dendritic development. Neurosci Bull 2015, PMID: 25732528.

1.Ding, X.; He, Z.; Shi, Y.; Wang, Q.; Wang, Y.*, Targeting TRPC6 channels in oesophageal carcinoma growth. Expert Opin Ther Targets 2010, PMID: 20235901.

   #, Equal contribution; *, Corresponding author.

PRESENTATIONS

2023   Speaker, ADPD2023, 17th International Conference on Alzheimer’s & 

           Parkinson’s Diseases, Gothenburg, Sweden

2023   Section organizer and speaker, 16th Annual Meeting of Chinese 

           Neuroscience Society, Zhuhai, Guangdong, China

2023   Speaker, 18th Annual Meeting of Chinese Cell Biology Society, Suzhou, 

           Jiangsu, China

2022   Section organizer and speaker, 15th Annual Meeting of Chinese 

           Neuroscience Society, Suzhou, Jiangsu, China

2021   Invited speaker, 5th Annual Meeting of the Neurodegenerative Branch of the Chinese 

           Neuroscience Society, Hangzhou, Zhejiang, China

2021   Invited seminar speaker, IDG/McGovern Institute for Brain Research at 

           Tsinghua University, Beijing, China

2021   Speaker, 2nd Frontier Symposium on Neurodegenerative Diseases, 

           Jiujiang, Jiangxi, China

2019   Speaker, Alzheimer’s Association International Conference, Los 

           Angeles, CA, USA

2019   Speaker, Keystone Symposium: Neurodegenerative Diseases, 

           Keystone, Co, USA

2019   Invited speaker, 4th International Symposium on Animal Models of Diseases,

           Institute of Genetics and Developmental Biology, CAS, Beijing, China

2019   Invited seminar speaker, Northwestern University, Chicago, IL, US

2019   Invited seminar speaker, UTHealth, Huston, TX, US

2019   Invited speaker, Penn CNS Injury Seminar, Philadelphia, PA, USA

2018   Poster Presentation, Keystone Symposia conference Advances in 

           Neurodegenerative Disease Research and Theraphy, Keystone, CO, USA

2017   Invited speaker, 2017 Marian S. Ware Research Retreat at University of

           Pennsylvania, PA, USA

2016   Poster Presentation, Keystone Symposia conference Advances in

           Neurodegenerative Disease Research and Theraphy, Keystone, CO, USA

           Invited speaker, 2016 Biomedical Postdoctoral Research Symposium at 

           University of Pennsylvania, PA, USA

2012   Poster Presentation, Cold Spring Harbor Asia Conference, China

2011   Oral presentation, The 9th Biennial Conference of the Chinese Neuroscience 

           Society and the 5th Member Congress, China

SERVICE

2023-   Peer reviewer Neuron

2023-   Peer reviewer Science Advances

2020-   Peer reviewer PNAS

2019-   Peer reviewer Molecular Degeneration

2016-   Peer reviewer PLOS ONE

2016-   Peer reviewer Frontiers in Aging Neuroscience

2016-   Peer reviewer Journal of Neural Transmission

2016-   Peer reviewer Neuropsychiatric Disease and Treatment

2015-   Peer reviewer Neuroscience Letters

2015-   Peer reviewer Journal of Alzheimer’s Disease

2015-   Peer reviewer Neuroscience

2015-   Peer reviewer Journal of NeuroOncology