Significant Works

1.  Han, Y.#; Li, J.#; Xia, W.#; Li, Q.; Sun, Z.; Zeng, W.; Hu, Y.; Luk, K.C.; Liu, C.*; Xiang, S.*; He, Z.*, Fibril fuzzy coat is important for α-synuclein pathological transmission activity. Neuron 2025, PMID: 40215967.

   ☆Highlighted with commentary by Joel C. Watts: Shedding light on the α-synuclein fibril fuzzy coat. Neuron 2025, PMID: 40472811.

2. Zhao X.#; Zeng W.#; Xu H.#; Sun Z.; Hu Y.; Peng B.; McBride, J.D.; Duan J.; Zhang B.; Kim S.J.; Zoll B.; Saito T.; Sasaguri H.; Saido T.C.; Ballatore C.; Yao H.; Wang Z.; Trojanowski J.Q.; Brunden K.R.; Lee V.M.Y.*; He Z.*. A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Sci. Transl. Med. 2023, PMID: 37703352.

3. He, Z.*; McBride, J. D.; Xu, H.; Changolkar, L.; Kim, S. J.; Zhang, B.; Narasimhan, S.; Gibbons, G. S.; Guo, J. L.; Kozak, M.; Schellenberg, G. D.; Trojanowski, J. Q.; Lee, V. M.*, Transmission of tauopathy strains is independent of their isoform composition. Nat Commun 2020, PMID: 31911587.

4. He, Z.; Guo, J. L.; McBride, J. D.; Narasimhan, S.; Kim, H.; Changolkar, L.; Zhang, B.; Gathagan, R. J.; Yue, C.; Dengler, C.; Stieber, A.; Nitla, M.; Coulter, D. A.; Abel, T.; Brunden, K. R.; Trojanowski, J. Q.; Lee, V. M.*, Amyloid-beta plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nat Med 2018, PMID: 29200205.

5. He, Z.; Jia, C.; Feng, S.; Zhou, K.; Tai, Y.; Bai, X.; Wang, Y.*, TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIa in rat hippocampal neurons. J Neurosci 2012, PMID: 22764246.

6. Ding, X.#; He, Z.#; Zhou, K.#; Cheng, J.; Yao, H.; Lu, D.; Cai, R.; Jin, Y.; Dong, B.; Xu, Y.; Wang, Y.*, Essential role of TRPC6 channels in G2/M phase transition and development of human glioma. J Natl Cancer Inst 2010, PMID: 20554944.

7. Shi, Y.#; Ding, X#.; He, Z.#; Zhou, K. C.; Wang, Q.; Wang, Y.*, Critical role of TRPC6 channels in G2 phase transition and the development of human oesophageal cancer. Gut 2009, PMID: 19651628.

#, Equal contribution; *, Corresponding author.