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1. Li, W.*, Shan, B., Zou, C., Wang, H., Zhang, M. M., Zhu, H., Naito, M. G., Xu, D., Manuel, V. J., Mifflin, L., Hou, Z., Ravits, J. & Yuan, J.* Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response. Cell Res, doi:10.1038/s41422-022-00673-3 (2022).

2Li, W.*# & Yuan, J.*# Targeting RIPK1 kinase for modulating inflammation in human diseases. Front Immunol 14, 1159743, doi:10.3389/fimmu.2023.1159743 (2023).

3Tao, P.#, Sun, J.#, Wu, Z.#, Wang, S.#, Wang, J.#, Li, W.#, Pan, H., Bai, R., Zhang, J., Wang, Y., Lee, P. Y., Ying, W., Zhou, Q., Hou, J., Wang, W., Sun, B., Yang, M., Liu, D., Fang, R., Han, H., Yang, Z., Huang, X., Li, H., Deuitch, N., Zhang, Y., Dissanayake, D., Haude, K., McWalter, K., Roadhouse, C., MacKenzie, J. J., Laxer, R. M., Aksentijevich, I., Yu, X., Wang, X., Yuan, J. & Zhou, Q. A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature 577, 109-114, doi:10.1038/s41586-019-1830-y (2020).

4Li, W., Zhang, Z., Liu, X., Cheng, X., Zhang, Y., Han, X., Zhang, Y., Liu, S., Yang, J., Xu, B., He, L., Sun, L., Liang, J. & Shang, Y. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J Clin Invest 127, 3421-3440, doi:10.1172/JCI94233 (2017).

5 Naito, M. G., Xu, D., Amin, P., Lee, J., Wang, H., Li, W., Kelliher, M., Pasparakis, M. & Yuan, J. Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. Proc Natl Acad Sci U S A 117, 4959-4970, doi:10.1073/pnas.1916427117 (2020).

6Su, Z., Dziedzic, S. A., Hu, D., Barrett, V. J., Broekema, N., Li, W., Qian, L., Jia, N., Ofengeim, D., Najafov, A., Zhu, H., Knipe, D. M. & Yuan, J. ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner. Cell Death Differ 26, 1077-1088, doi:10.1038/s41418-018-0215-3 (2019).

7Xu, D., Jin, T., Zhu, H., Chen, H., Ofengeim, D., Zou, C., Mifflin, L., Pan, L., Amin, P., Li, W., Shan, B., Naito, M. G., Meng, H., Li, Y., Pan, H., Aron, L., Adiconis, X., Levin, J. Z., Yankner, B. A. & Yuan, J. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Cell 174, 1477-1491 e1419, doi:10.1016/j.cell.2018.07.041 (2018).

8He, L., Liu, X., Yang, J., Li, W., Liu, S., Liu, X., Yang, Z., Ren, J., Wang, Y., Shan, L., Guan, C., Pei, F., Lei, L., Zhang, Y., Yi, X., Yang, X., Liang, J., Liu, R., Sun, L. & Shang, Y. Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis. Cell Res 28, 934-951, doi:10.1038/s41422-018-0079-6 (2018).

9Xie, G., Liu, X., Zhang, Y., Li, W., Liu, S., Chen, Z., Xu, B., Yang, J., He, L., Zhang, Z., Jin, T., Yi, X., Sun, L., Shang, Y. & Liang, J. UTX promotes hormonally responsive breast carcinogenesis through feed-forward transcription regulation with estrogen receptor. Oncogene 36, 5497-5511, doi:10.1038/onc.2017.157 (2017).

10Liu, Y., Liu, S., Yuan, S., Yu, H., Zhang, Y., Yang, X., Xie, G., Chen, Z., Li, W., Xu, B., Sun, L., Shang, Y. & Liang, J. Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks. J Mol Cell Biol 9, 178-194, doi:10.1093/jmcb/mjx013 (2017).

11Liu, X., Si, W., Liu, X., He, L., Ren, J., Yang, Z., Yang, J., Li, W., Liu, S., Pei, F., Yang, X. & Sun, L. JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component. Mol Cancer 16, 175, doi:10.1186/s12943-017-0744-2 (2017).

12Liu, S., Yu, H., Liu, Y., Liu, X., Zhang, Y., Bu, C., Yuan, S., Chen, Z., Xie, G., Li, W., Xu, B., Yang, J., He, L., Jin, T., Xiong, Y., Sun, L., Liu, X., Han, C., Cheng, Z., Liang, J. & Shang, Y. Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. Mol Cell 67, 853-866 e855, doi:10.1016/j.molcel.2017.07.011 (2017).

13Li, L., Liu, X., He, L., Yang, J., Pei, F., Li, W., Liu, S., Chen, Z., Xie, G., Xu, B., Ting, X., Zhang, Z., Jin, T., Liu, X., Zhang, W., Yuan, S., Yang, Z., Wu, C., Zhang, Y., Yang, X., Yi, X., Liang, J., Shang, Y. & Sun, L. ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nat Commun 8, 691, doi:10.1038/s41467-017-00702-5 (2017).

14Chen, Z., Gui, B., Zhang, Y., Xie, G., Li, W., Liu, S., Xu, B., Wu, C., He, L., Yang, J., Yi, X., Yang, X., Sun, L., Liang, J. & Shang, Y. Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly. J Biol Chem 292, 18113-18128, doi:10.1074/jbc.M117.797357 (2017).

15Zhang, Y., Zhang, D., Li, Q., Liang, J., Sun, L., Yi, X., Chen, Z., Yan, R., Xie, G., Li, W., Liu, S., Xu, B., Li, L., Yang, J., He, L. & Shang, Y. Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering. Nat Genet 48, 1003-1013, doi:10.1038/ng.3635 (2016).

16Shan, L., Zhou, X., Liu, X., Wang, Y., Su, D., Hou, Y., Yu, N., Yang, C., Liu, B., Gao, J., Duan, Y., Yang, J., Li, W., Liang, J., Sun, L., Chen, K., Xuan, C., Shi, L., Wang, Y. & Shang, Y. FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Cancer Cell 30, 708-722, doi:10.1016/j.ccell.2016.09.010 (2016).

17Li, L., Shi, L., Yang, S., Yan, R., Zhang, D., Yang, J., He, L., Li, W., Yi, X., Sun, L., Liang, J., Cheng, Z., Shi, L., Shang, Y. & Yu, W. SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun 7, 12235, doi:10.1038/ncomms12235 (2016).

18Yan, R., He, L., Li, Z., Han, X., Liang, J., Si, W., Chen, Z., Li, L., Xie, G., Li, W., Wang, P., Lei, L., Zhang, H., Pei, F., Cao, D., Sun, L. & Shang, Y. SCF(JFK) is a bona fide E3 ligase for ING4 and a potent promoter of the angiogenesis and metastasis of breast cancer. Genes Dev 29, 672-685, doi:10.1101/gad.254292.114 (2015).

19Si, W., Huang, W., Zheng, Y., Yang, Y., Liu, X., Shan, L., Zhou, X., Wang, Y., Su, D., Gao, J., Yan, R., Han, X., Li, W., He, L., Shi, L., Xuan, C., Liang, J., Sun, L., Wang, Y. & Shang, Y. Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell 27, 822-836, doi:10.1016/j.ccell.2015.04.011 (2015).

20Yang, X., Yang, J., Li, L., Sun, L., Yi, X., Han, X., Si, W., Yan, R., Chen, Z., Xie, G., Li, W., Shang, Y. & Liang, J. PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis. FASEB J 28, 4821-4834, doi:10.1096/fj.14-254045 (2014).

21Wang, F., He, L., Huangyang, P., Liang, J., Si, W., Yan, R., Han, X., Liu, S., Gui, B., Li, W., Miao, D., Jing, C., Liu, Z., Pei, F., Sun, L. & Shang, Y. JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation. PLoS Biol 12, e1001819, doi:10.1371/journal.pbio.1001819 (2014).

22Han, X., Gui, B., Xiong, C., Zhao, L., Liang, J., Sun, L., Yang, X., Yu, W., Si, W., Yan, R., Yi, X., Zhang, D., Li, W., Li, L., Yang, J., Wang, Y., Sun, Y. E., Zhang, D., Meng, A. & Shang, Y. Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Mol Cell 55, 482-494, doi:10.1016/j.molcel.2014.06.006 (2014).


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