学历: 博士研究生
邮箱: dbma@sioc.ac.cn
电话:
地址: 上海市浦东新区海科路100号13号楼邮编:201210
2023年8月-至今,中国科学院生物与化学交叉研究中心,课题组长
2017年2月-2023年7月,美国霍华德休斯医学研究所/布兰迪斯大学,博士后
(师从于2017年诺贝尔生理学或医学奖得主Michael Rosbash教授)
2011年9月-2017年1月,中国科学院上海生命科学研究院,博士
2007年9月-2011年6月,四川农业大学,学士
马定邦课题组开发和应用多种高通量单细胞组学研究技术,例如单细胞RNA sequencing等,结合生物信息学、分子生物学、遗传学、细胞生物学以及动物行为学,在单细胞和神经环路水平深入研究生物节律的分子调控机制以及生物节律与衰老和神经退行性疾病的关系。
1. Ma D,Ojha P,Yu AD,Araujo MS,Luo W,Keefer E,Díaz MM,Wu M,Joiner WJ,Abruzzi KC,Rosbash M. Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2321338 121.
2. Le JQ,Ma D,Dai X,Rosbash M. Light and dopamine impact two circadian neurons to promote morning wakefulness. bioRxiv. 2024 Mar 8:2024.03.04.583333.
3. Ma D,Herndon N,Le JQ,Abruzzi KC,Zinn K,Rosbash M. Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the Drosophila adult brain. Sci Adv. 2023 Feb 22;9(8):eade8500.
4. Ma D,Przybylski D,Abruzzi KC,Schlichting M,Li Q,Long X,Rosbash M. A transcriptomic taxonomy of Drosophila circadian neurons around the clock. Elife. 2021 Jan 13;10:e63056.
5. Ma D,Li X,Guo Y,Chu J,Fang S,Yan C,Noel JP,Liu H. Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):224-9.
6. Li X,Ma D,Lu SX,Hu X,Huang R,Liang T,Xu T,Tobin EM,Liu H. Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock. Plant Cell. 2016 Nov;28(11):2755-2769. (共同第一作者)
7. Yu AD,Galatsis K,Zheng J,Le JQ,Ma D,Perlman S,Rosbash M. Development of a Saliva-Optimized RT-LAMP Assay for SARS-CoV-2. J Biomol Tech. 2021 Sep;32(3):102-113.
8. Hobin M,Dorfman K,Adel M,Rivera-Rodriguez EJ,Kuklin EA,Ma D,Griffith LC. The Drosophila microRNA bantam regulates excitability in adult mushroom body output neurons to promote early night sleep. iScience. 2022 Aug 1;25(9):104874.
9. Schlichting M,Richhariya S,Herndon N,Ma D,Xin J,Lenh W,Abruzzi K,Rosbash M. Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2206066119.
10. Liu Y,Li X,Ma D,Chen Z,Wang JW,Liu H. CIB1 and CO interact to mediate CRY2-dependent regulation of flowering. EMBO Rep. 2018 Oct;19(10):e45762.
11. Wang F,Gao Y,Liu Y,Zhang X,Gu X,Ma D,Zhao Z,Yuan Z,Xue H,Liu H. BES1-regulated BEE1 controls photoperiodic flowering downstream of blue light signaling pathway in Arabidopsis. New Phytol. 2019 Aug;223(3):1407-1419.
12. Li X,Liu C,Zhao Z,Ma D,Zhang J,Yang Y,Liu Y,Liu H. COR27 and COR28 Are Novel Regulators of the COP1-HY5 Regulatory Hub and Photomorphogenesis in Arabidopsis. Plant Cell. 2020 Oct;32(10):3139-3154.