06-262025
Cell Metabolism | Xu Daichao’s Team Identifies a Methionine Metabolism Sensor that Regulates Cell Death
In summary, this study identifies RIPK1 as a novel sensor for SAM abundance, capable of responding to methionine and SAM metabolic changes to control cell fate decisions. SAM deficiency contributes to the development of diseases related to cell death and inflammation. Given that RIPK1 inhibitors have shown promise in clinical trials for various inflammatory and degenerative diseases, this research suggests RIPK1 as a potential therapeutic target for human diseases associated with SAM dysregulation.
