Xinbo Wang, Ph.D.
Email: xinbo.wang@mail.sioc.ac.cn
Phone:
Office: Room 525, Building 13, Haike Rd 100, Shanghai, China 201210
Website:
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Biography
2026 – Present Investigator, Interdisciplinary Research Center on Biology and Chemistry （IRCBC）, Chinese Academy of Sciences
2024 – 2026 Associate Research Scientist, Yale University
2019 – 2024 Postdoctoral Associate, Yale University
2017 – 2018 Research Assistant, Institute of Biophysics, Chinese Academy of Sciences
2011 – 2017 Doctor of Philosophy in Cell Biology, Nankai University
Dr. Wang earned his Ph.D. from Nankai University under the mentorship of Dr. Junjie Hu, where his research focused on the functional organization of endoplasmic reticulum (ER) tubular networks. During his doctoral studies, he developed a system to isolate ER tubular fractions, enabling the characterization of proteins enriched in this ER subdomain. This work uncovered the functional diversity of ER tubules and identified novel associated proteins and pathways. He subsequently joined the laboratory of Dr. Pietro De Camilli at Yale University for postdoctoral training, where he investigated cellular lipid transfer and membrane dynamics, with a particular emphasis on proteins linked to Parkinson’s disease (PD). His research revealed that two PD-associated proteins, VPS13C and LRRK2, play essential roles in the lysosomal damage response pathway. In January 2026, Dr. Wang joined the IRCBC as a Principal Investigator, with a research focus on the mechanisms governing lysosomal homeostasis.
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Research
The Wang Lab focuses on elucidating the molecular mechanisms that maintain lysosomal homeostasis and on understanding how their dysfunction drives neurodegenerative diseases, including Parkinson’s and Alzheimer’s. By investigating how cells sense, repair, and remove damaged lysosomes—and why these processes fail in disease—the lab aims to uncover fundamental principles of lysosomal regulation and explore their therapeutic potential.
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Publications
Bodan Hu, Daniel Alvarez, Cristian Rocha-Roa, Valentin Guyard, Dazhi Li, Xinbo Wang, Pietro De Camilli, Stefano Vanni, and Karin Reinisch; Molecular insights into bulk lipid transport from structural studies of the bridge-like protein VPS13A complexed with the scramblase XKR1, bioRxiv, 2026.
Dazhi Li, Xinbo Wang, Bodan Hu, Hongyan Hao, Stephanie Hamill, Yuting Li, Guochao Chen, Pietro De Camilli, Karin M. Reinisch; Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C, bioRxiv 2025.
Xinbo Wang; Peng Xu; Amanda Bentley-DeSousa; William Hancock-Cerutti; Shujun Cai; Benjamin T. Johnson; Francesca Tonelli; Lin Shao; Gabriel Talaiq; Dario R. Alessi; Shawn M. Ferguson; Pietro De Camilli; The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts following lysosome damage, Nature Cell Biology, 2025.
Xinbo Wang; Javier Espadas; Yumei Wu; Shujun Cai; Jinghua Ge; Lin Shao; Aurelien Roux; Pietro De Camilli; Membrane remodeling properties of the Parkinson’s disease protein LRRK2, Proceedings of the National Academy of Sciences, 2023, 120(43).
Daehun Park; Yumei Wu; Xinbo Wang; Swetha Gowrishankar; Aaron Baublis; Pietro De Camilli; Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates, Nature Communications, 2023, 14(1): 455.
Xinbo Wang; Shanshan Li; Haicheng Wang; Wenqing Shui; Junjie Hu; Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae, eLife, 2017, 6.
