韦海/ 研究员
学历: 博士研究生
邮箱: hai.wei@mail.sioc.ac.cn
电话: 021-68582396
地址: 上海市浦东新区海科路100号#13楼205邮编：201210
10/2024-present， 中国科学院生物与化学交叉研究中心，研究员、课题组长
02/2020-09/2024，美国西南医学中心药学系，博士后
05/2019-12.2019，德国慕尼黑大学，junior researcher
10/2014-05/2019，德国慕尼黑大学发育生物学系，博士研究生
09/2011-07/2014，山东农业大学（中科院遗传与发育生物学研究所客座研究生），硕士
09/2007-07/2011，山东农业大学，学士
韦海研究员致力于以线虫和哺乳动物为模型进行stress response，lipotoxicity，cellular toxicity与aging发面的研究，研究方向主要包括以下方面：1). caspase如何参与调控脂毒性胁迫和慢性UV辐射胁迫导致的衰老病变机制。 2). 遗传筛选并鉴定调控慢性UV辐射胁迫损伤的关键响应因子及其机理研究。3). 遗传筛选并鉴定调控慢性UV辐射胁迫损伤的关键响应因子及其机理研究；4). 筛选并鉴定缓解细胞毒性蛋白（i.e. Aβ, α-Syn, poly-Q）的关键调节因子及其机理研究。韦海研究员曾获得2023年度美国西南医学中心Alfred & Mabel Gilman Memorial Excellence Scientific Award。此外，课题组还获得国家海外优秀青年基金，上海白玉兰青年人才项目，中国科学院“BR”项目的资助和支持。
Representative publications (#equal contribuution *corresponding author)：
· Hai Wei, Yi M. Weaver, Benjamin P. Weaver 2024 Xeroderma pigmentosum protein XPD controls caspase- mediated stress responses. Nature Communications PMID: 39472562, DOI:https://doi.org/10.1038/ s41467-024-53755-8
· Hai Wei, Yi M. Weaver, Chendong Yang, Yuan Zhang, Guoli Hu, Courtney M. Karner, Matthew Sieber, Ralph J. DeBerardinis and Benjamin P. Weaver 2024 Proteolytic Activation of Fatty Acid Synthase Signals Pan-Stress Resolution. Nature Metabolism. PMID: 38167727, DOI: 10.1038/s42255-023-00939-z (Cover Article, Highlighted and collected by Nature Metabolism)
· Aditya Sethi#, Hai Wei#, Nikhil Mishra, Ioannis Segos, Eric J. Lambie, Esther Zanin and Barbara Conradt 2022 A caspase-RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans. PLOS Biology PMID: 36201522, DOI: 10.1371/journal.pbio.3001786 (#equal contribution)
· Hai Wei, Lambie EJ, Oso´rio DS, Carvalho AX, Conradt B. 2020 PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning. PLOS Genetics PMID: 32946434, DOI: 10.1371/journal.pgen.1008912
· W. Deng, Jack A. Bates, Hai Wei, Michael D. Bartoschek, Barbara Conradt & Heinrich Leonhardt, 2020 Tunable light and drug induced depletion of target proteins. Nature Communications PMID: 31949141, DOI:10.1038/s41467-019 -14160-8
· Mishra N., Hai Wei, and B. Conradt, 2018 Caenorhabditis elegans ced-3 Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die. GENETICS PMID: 30194072, DOI:10.1534/genetics. 118.301500
· Hai Wei#, Bo Yan#, J. Gagneur, and B. Conradt, 2017 Caenorhabditis elegans ces-1 Snail represses pig-1 MELK expression to control asymmetric cell division. GENETICS PMID: 28652378, DOI:10.1534/genetics.117.202754 (#equal contribution)
· Qingliang Li#, Hai Wei#, Lijing Liu, Xiaoyuan Yang, Xiansheng Zhang, Qi Xie, 2017 Unfolded protein response activation compensates endoplasmic reticulum-associated degradation deficiency in Arabidopsis. Journal of Integrative Plant Biology PMID: 28418178, DOI: 10.1111/jipb.12544 (#equal contribution)
