2024年5月-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长
2021年5月-2024年4月 德国海德堡大学医院 课题负责人
2019年8月-2021年4月 德国亥姆霍兹研究所慕尼黑中心 博士后
2014年11月-2019年7月 德国慕尼黑大学 博士学位
2010年9月-2013年7月 兰州大学生命科学学院 硕士学位
2006年9月-2010年6月 兰州大学生物技术基地班 学士学位

1、 全身组织透明成像技术的进一步优化与研发
2、 研究神经退行性疾病引起的全身系统性病变
3、 研究神经系统与全身范围癌转移的相互作用

1. Chenchen Pan*, Oliver Schoppe*, Arnaldo Parra-Damas*, Ruiyao Cai, Mihail Ivilinov Todorov, Gabor Gondi, Bettina von Neubeck, Nuray Bögürcü-Seidel, Sascha Seidel, Katia Sleiman, Christian Veltkamp, Benjamin Fo¨rstera, Hongcheng Mai, Zhouyi Rong, Omelyan Trompak, Alireza Ghasemigharagoz, Madita Alice Reimer, Angel M. Cuesta, Javier Coronel, Irmela Jeremias, Dieter Saur, Amparo Acker-Palmer, Till Acker, Boyan K. Garvalov, Bjoern Menze, Reinhard Zeidler, and Ali Ertürk. (2019). Deep learning reveals cancer metastasis and therapeutic antibody targeting in the entire body. Cell 179, 1661-1676 e1619. (封面论文)

https://www.cell.com/cell/fulltext/S0092-8674(19)31269-3

2. Ruiyao Cai*, Chenchen Pan*, Alireza Ghasemigharagoz, Mihail Ivilinov Todorov, Benjamin Förstera, Shan Zhao, Harsharan S. Bhatia, Arnaldo Parra-Damas, Leander Mrowka, Delphine Theodorou, Markus Rempfler, Anna L. R. Xavier , Benjamin T. Kress, Corinne Benakis, Hanno Steinke, Sabine Liebscher, Ingo Bechmann, Arthur Liesz, Bjoern Menze, Martin Kerschensteiner , Maiken Nedergaard and Ali Ertürk. (2019). Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull-meninges connections. Nature neuroscience 22, 317-327. (封面论文)

https://www.nature.com/articles/s41593-018-0301-3

3. Chenchen Pan*, Ruiyao Cai*, Francesca Paola Quacquarelli*, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, Paweł Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali Ertürk. (2016) Shrinkage-mediated imaging of entire organs and organisms using uDISCO. Nature methods 13, 859-867. (封面论文)

https://www.nature.com/articles/nmeth.3964

4. Chenchen Pan, Frank Winkler. (2022) Insights and opportunities at the crossroads of cancer and neuroscience. Nature Cell Biology 24 (10), 1454-1460.

https://www.nature.com/articles/s41556-022-00978-w

5. Ruiyao Cai*, Zeynep Ilgin Kolabas*, Chenchen Pan, Hongcheng Mai, Shan Zhao, Doris Kaltenecker, Fabian F. Voigt, Muge Molbay, Tzu-lun Ohn, Cécile Vincke, Mihail I. Todorov, Fritjof Helmchen, Jo A. Van Ginderachter, Ali Ertürk. (2023) Whole-mouse clearing and imaging at the cellular level with vDISCO. Nature Protocols 18, 1197–1242 (2023). (封面论文)

https://www.nature.com/articles/s41596-022-00788-2

6. Tim Gruber, Chenchen Pan, Raian E. Contreras, Tobias Wiedemann, Donald A. Morgan, Alicja A. Skowronski, Sandrine Lefort, Cahue De Bernardis Murat, Ophelia Le Thuc, Beata Legutko, Francisco J. Ruiz-Ojeda, Maria de la Fuente-Fernández, Angel Luis Garcia-Villalon, Daniel González-Hedström, Melanie Huber, Klara Szigeti-Buck, Timo D. Müller, Siegfried Ussar, Paul Pfluger, Steve C. Woods, Ali Ertürk, Charles A. LeDuc, Kamal Rahmouni, Miriam Granado, Tamas L. Horvath, Matthias H. Tschöp, Cristina García-Cáceres. (2021) Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metabolism 33 (6), 1155-1170. e10.

https://www.cell.com/action/showPdf?pii=S1550-4131%2821%2900173-X

7. Oliver Schoppe, Chenchen Pan, Javier Coronel, Hongcheng Mai, Zhouyi Rong, Mihail Ivilinov Todorov, Annemarie Müskes, Fernando Navarro, Hongwei Li, Ali Ertürk, Bjoern H. Menze. (2020) Deep learning-enabled multi-organ segmentation in whole-body mouse scans. Nature communications 11 (1), 1-14.

https://www.nature.com/articles/s41467-020-19449-7

8. Douglas S. Richardson, Webster Guan, Katsuhiko Matsumoto, Chenchen Pan, Kwanghun Chung, Ali Ertürk, Hiroki R. Ueda, Jeff W. Lichtman. (2021) Tissue clearing. Nature Reviews Methods Primers 1 (1), 1-24.

https://www.nature.com/articles/s43586-021-00080-9

9. Bettina von Neubeck*, Gabor Gondi*, Chiara Riganti , Chenchen Pan, Arnaldo Parra Damas, Hagen Scherb, Ali Ertürk, Reinhard Zeidler. (2018) An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. International Journal of Cancer 143, 2065-2075.

https://onlinelibrary.wiley.com/doi/10.1002/ijc.31607

10. Leo M Miyakoshi, Frederik F Stæger, Qianliang Li, Chenchen Pan, Lulu Xie, Hongyi Kang, Chiara Pavan, Juliana Dang, Qian Sun, Ali Ertürk, Maiken Nedergaard. (2023) The state of brain activity modulates cerebrospinal fluid transport. Progress in Neurobiology 229, 102512.

https://www.sciencedirect.com/science/article/abs/pii/S0301008223001132?via%3Dihub

11. Katharina Schregel, Lennart Heinz, Jessica Hunger, Chenchen Pan, Julia Bode, Manuel Fischer, Volker Sturm, Varun Venkataramani, Kianush Karimian-Jazi, Dennis A Agardy, Yannik Streibel, Roland Zerelles, Wolfgang Wick, Sabine Heiland, Theresa Bunse, Björn Tews, Michael Platten, Frank Winkler, Martin Bendszus, Michael O Breckwoldt. (2023) A Cellular Ground Truth to Develop MRI Signatures in Glioma Models by Correlative Light Sheet Microscopy and Atlas-Based Coregistration. The Journal of Neuroscience 43, 5574.

https://www.jneurosci.org/content/43/30/5574/tab-article-info

* indicates co-first authors