1. 阿尔茨海默病（AD）的病理发生机理。

主要关注AD相关神经退行性疾病（ADRD）的病理发生机理。以这一类疾病中的蛋白病理性变化为切入点，研究病理蛋白在神经细胞内变性发生的初始分子机制以及跨脑区传播的细胞生物学机理。

2. 开发新型的ADRD研究模型。

针对ADRD研究模型不佳的领域瓶颈问题，通过多种手段，在多种属动物上建立新型动物模型，更具疾病相关性地在动物上模拟ADRD病人脑中发生的神经病理病变，为ADRD研究领域提供新的研究模型，以及验证检测、干预手段的新平台。

3. 发展ADRD的早期诊断方法及干预。

制备特异识别疾病关联度高的生物标志物的抗体或者化合物，开发ADRD的早期诊断及精准干预的新策略和新方法。

Research area:

1. The pathogenesis mechanisms underlying the neurodegenerative diseases.

We study Alzheimer’s disease (AD) and related diseases (ADRD), from the perspective of protein pathogenesis. We are trying to understand how the protein pathogenesis initiates and spreads within the disease brain from the molecular and cellular levels, and how such process contributes to the disease progression.  

2. Establish new ADRD animal models.

Lacking good animal models is a bottleneck problem in ADRD research. We are generating novel animal models to recapitulate the patient-like pathogenesis process in the animal models, aiming to provide better platforms for the disease mechanism research and translational application.  

3. Develop new diagnosis and intervention of ADRD.

Generating antibodies and small molecules that specifically recognizing disease-related pathological biomarkers, and developing new strategies and methods for the early diagnosis and precise intervention of ADRD.