2023.11-至今 中国科学院生物与化学交叉研究中心，研究员、课题组长

2018.9-2023.9 加州大学圣迭戈分校，博士后

2017.2-2018.1 中国科学院生化细胞所，博士后

2010.6-2017.1 中国科学院生化细胞所，博士

2006.9-2010.6 浙江工业大学，学士

（1）利用交叉学科（生物学、数学和工程学）探究细胞网络在衰老过程中的底层运行逻辑；

（2）基于细胞网络的设计原则和计算机模拟仿真，改造和合成细胞通路，实现可编程的细胞动态过程，并将此技术应用到疾病治疗、抗衰老和生物技术等诸多领域。

• Zhou Z, Liu YT, Feng YS, Klepin S, Tsimring LS, Pillus L, Hasty J, Hao N. (2023) Engineering longevity – design of a synthetic gene oscillator to slow cellular aging. Science. 2023;380,376-381. PMID:37104589

• Liu Y*, Zhou Z*, Wu SL, Klepin S, Tsimring LS, Pillus L, Hasty J, and Hao N. Enhanced cellular longevity arising from environmental fluctuations. bioRxiv. 2023 *equal contribution

• Paxman J*, Zhou Z*, O'Laughlin R, Liu Y, Li Y, Tian W, Su H, Jiang Y, Holness SE, Stasiowski E, Tsimring LS, Pillus L, Hasty J, Hao N. (2022) Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis. eLife. doi: 10.7554/eLife.75978. PMID: 36194205 *equal contribution

• Zhou Z*, Liu YT*, Gong T, Ma L, Hu YN, Li HT, Cai C, Zhang LL, Wei G, Zhou JQ. (2017) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription. eLife. doi: 10.7554 PMID: 29027902 *equal contribution

• Gong T, Liu YT, Zhou Z, Zhang LL, Gu X, Wen Y, Zhong WL, Xu GL and Zhou JQ. (2018) Combinatorial K4me0-K36me3 marks on sister histone H3s are required for Dnmt3a-Dnmt3L mediated de novo DNA methylation. J Genet Genomics. 47(2):105-114 PMID: 32173286

• Lv FJ, Zhang TL, Zhou Z, Gao SX, Wong CL, Zhou JQ and Ding JP. (2015) Structural basis for Sfm1 functioning as a protein arginine methyltransferase. Cell discov. 1:15037. PMID: 27462434

• Li HT, Gong T, Zhou Z, Liu YT, Cao X, Yang H, Chen CD, Zhou JQ. (2015) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochem J. 467(3):507-15. PMID: 25715670

• Qian H, Chen W, Li J, Wang J, Zhou Z, Liu W, Fu Z. (2009) The effect of exogenous nitric oxide on alleviating herbicide damage in Chlorella vulgaris. Aquat Toxicol. 17;92 (4):250-7. PubMed PMID: 19297032