06-132025
PNAS | A New Mechanism of PARP12 in Regulating Cell Death and Antiviral Immunity
This work provides several important advances: (1) it identifies PARP12 as a novel regulator of cell death pathways, (2) elucidates a previously unknown mechanism of RIPK1/3 regulation through MARylation, and (3) reveals a molecular checkpoint that coordinates cell death and antiviral immune responses. These findings not only deepen our understanding of host-virus interactions but also suggest PARP12 as a potential therapeutic target for influenza and other viral infections.
