1998-2002  吉林大学  学士   Jilin University   B.S.
2002-2008  北京大学  博士   Peking University   Ph.D
2008-2013  美国加州大学洛杉矶分校&霍华德休斯医学院  博士后  UCLA&HHMI Postdoc
2013.9-至今 中国科学院生物与化学交叉研究中心 研究员、课题组长

1.与神经退行性疾病如老年痴呆症、帕金森症， 亨廷顿氏病相关的蛋白质的错误折叠，异常积聚，和淀粉样化的分子机理研究。
2.基于重要生物靶点分子结构的小分子药物先导物的设计，筛选和优化。主要针对老年痴呆症和帕金森症相关的致病蛋白多聚体及淀粉样纤维的分子结构，进行小分子及多肽化合物的合理设计，筛选，及基于此先导物的机理和功能研究。
3.基于淀粉样多肽的具有新功能的新材料设计，开发和应用。

1. Zeng, S.Y.¶, Zhang, S.Q.¶, Zhang, S.N.¶, Fan, Y.¶, Xia, W.C.¶, Chen, F.Y.¶, Huang, C.A., Lv, S.R., Lu, J.X., Sun, Y.P., Liu, K.E., Li, Y.X., Zhang, Y.Y., Wang, J., Liu, C. *, Li, D.* TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy. Cell, 2026.

2. Wu, K.M., Xu, Q.H., Liu, Y.Q., Feng, Y.W., Han, S.D., Zhang, Y.R., Chen, S.D., Guo, Y., Wu, B.S., Ma, L.Z., Zhang, Y., Chen, Y.L., Yang, L., Yao, Y.F., Xiao, Y.J., Wang, T.T., Zhao, J., Chen, S.F., Cui, M., Lu, B.X., Le, W.D., Shu, Y.S., Ye, K.Q., Li, J.Y., Li, W.S., Wang, J., Liu, C.*, Yuan, P. *, Yu, J.T. * Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson’s disease. Science, 2025.

3. Zhu, G.Y., Xie, J.J., Kong, W.N., Xie, J.F., Li, Y.C., Du, L., Zheng, Q.G., Sun, L., Guan, M.F., Li, H., Zhu, T.X., He, H., Liu, Z.Y., Xia, X., Kan, C., Tao, Y.Q., Shen, H.C., Li, D., Wang, S.Y., Yu, Y.G., Yu, Z.H., Zhang, Z.Y., Liu, C.*, Zhu, J.D., Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation. Cell, 2020.

4. Xiang, J., Tao, Y.Q., Xia, Y.Y., Luo, S.L., Zhao, Q.Y., Li, B.W., Zhang, X.Q., Sun, Y.P., Xia, W.C., Zhang, M.M., Kang, S.S., Ahn, E.H., Liu, X., Xie, F., Guan, Y.H., Yang, J.J., Bu, L.H., Wu, S.X., Wang, X.C., Cao, X.B., Liu, C., Zhang, Z.T., Li, D., Ye, K.Q.* Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies. Cell, 2023.

5. Zhang, J.Q.¶, Hu, J.J.¶, Liu, R.G.¶, Zhou, T., Luo, X.W., Liang, P.G., Xie, Z.C., Zhao, Q.Y., Chen, Y., Du, D., Liu, C., Zheng, Y.M., Li, D., Wang, B.* YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates. Nature Cell Biology, 2025.

6. Zhao, Q.Y., Tao, Y.Q., Yao, Y.X., Liu, K.E., Lv, S.R., Cui, B.Y., Xiao, W.D., Cao, T.Y., Li, W.D., Gao, F., Shen, Y., Wang, C., Ma, C., Qiu, W.Y., Liu, C.*, Li, D. Unraveling Alzheimer’s complexity with a distinct Aβ42 fibril type and specific AV-45 binding. Nature Chemical Biology, 2025.

7. Wang, H.L., Wang, Q., Xu, H.X., Wu, Y.Z., Siulam, C., Xu, Q.H., Pan, C.F., Cao, J.Y., Cao, Z.Y., Yang, R.N., Ding, Y., Fei, Y.Y., Chen, Y.F., Wang, J., Liu, C.*, Lu, B.X. MEK1/2 inhibitors suppress pathological α-synuclein and neurotoxicity in cell models and a humanized mouse model of Parkinson’s disease. Science Translational Medicine, 2025.

8. Wang, Q.W., Liu, Z.T., Wang, Y.J., Liu, Y., Chen, Y., Zhang, S.N., Zeng, W., Li, D., Yang, F., He, Z.H., Xiao, W.D., Liu, C.*, Wang, C. Quantitative chemoproteomics reveals dopamine’s protective modification of Tau. Nature Chemical Biology, 2025.

9. Xia, W.C., Xu, Z.X., Dong, H., Zhang, S.N., He, C.D., Li, D., Sun, B., Dai, B., Dong, S.W., Liu, C.*. Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications. Journal of the American Chemical Society, 2025.

10. Xu, Q.H., Wang, H.L., Yang, R.N., Tao, Y.Q., Wang, Z.Y., Zhang, S.N., Sun, B., Li, D., Lu, B.X., Liu, C.*. α-Synuclein amyloid fibril directly binds to LC3B and suppresses SQSTM1/p62-mediated selective autophagy. Cell Research, 2024.

11. Tao, Y.Q., Xu, P., Zhang, S.Q., Wei, S.G., Yang, G., Liu, K.E., Li, X., Sun, Y.P., Zhao, Q.Y., Li, D., Yu, B., Liu, C.*. Time-course remodeling and pathology intervention of α-synuclein amyloid fibril by heparin and heparin-like oligosaccharides. Nature Structural & Molecular Biology, 2024.

12. Zhang, S.Q., Xiang, H.J., Tao, Y.Q., Li, J., Zeng, S.Y., Xu, Q.H., Xiao, H.N., Lv, S.R., Song, C.W., Cheng, Y., Li, M., Zhu, Z.Y., Zhang, S.N., Sun, B., Li, D., Xiang, S.Q., Tan, L., Liu, C.*. Inhibitor Development for α-Synuclein Fibril’s Disordered Region to Alleviate Parkinson’s Disease Pathology. Journal of the American Chemical Society, 2024.

13. Li, D.N., Ma, Y.Y., Xia, W.C., Tao, Y.Q., Zhang, Y.L., Zhang, H., Li, D., Dai, B., Liu, C. * Creating an Amyloid ‘Kaleidoscope’ Using Short Iodinated Peptides. Angewandte Chemie International Edition, 2023.

14. Tao, Y.Q., Xia, W.C., Zhao, Q.Y., Xiang, H.J., Han, C., Zhang, S.Q., Gu, W., Tang, W.J, Li, Y., Tan, L., Li, D., Liu, C. * Structural mechanism for specific binding of chemical compounds to amyloid fibrils. Nature Chemical Biology, 2023.

15. Zhu, S.B., Gu, J.G., Yao, J.J., Li, Y.C., Zhang, Z.T., Xia, W.C., Wang, Z., Gui, X.R., Li, L.T., Li, D., Zhang, H., Liu, C. * Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis. Developmental Cell, 2022.

16. Zhang, S.N., Liu, Y.Q., Jia, C.Y., Lim, Y.J., Feng, G.Q., Xu, E.Q., Long, H.F., Kimura, Y., Tao, Y.Q., Zhao, C.Y., Wang, C.C., Liu, Z.Y., Hu, J.J., Ma, M.R., Liu, Z.J., Lin, J., Li, D., Wang, R.X., Dawson, V.L., Dawson, T.M., Li, Y.M., Mao, X.B., Liu, C. * Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson’s disease. Proceedings of the National Academy of Sciences of the United States of America, 2021.

17. Gu, J.G., Wang, C., Hu, R.F., Li, Y.C., Zhang, S.N., Sun, Y.P., Wang, Q.Q., Li, D., Fang, Y.S., Liu, C., Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation. Cell Research, 2021.

18. Sun, Y., Hou, S., Zhao, K., Long, H., Liu, Z., Gao, J., Zhang, Y., Su, X., Li, D., Liu, C. *, Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation. Cell Research, 2020.

19. Liu, Z.Y., Zhang, S.N., Gu, J.G., Tong, Y.L., Li, Y.C., Gui, X.R., Long, H.F., Wang, C.C., Zhao, C.Y., Lu, J.X., He, L., Li, Y., Liu, Z.J., Li, D., Liu, C.*, Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nature Structural & Molecular Biology, 2020.

20. Fan, Y., Zhao, Q.Y., Xia, W.C., Tao, Y.Q., Yu, W.B., Chen, M.J., Liu, Y.Q., Zhao, J., Sun, Y.P., Si, C.F., Zhang, S.Q., Zhang, Y.Y., Li, W.S., Liu, C. *, Wang, J. *, Li, D.* Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders. Cell Research, 2022.