1. Su T.,Lu Y.,Fu  C.,Geng Y., Chen Y. (2023)  GluN2A mediates ketamine-induced rapid antidepressant-like responses.Nature neuroscience  26:1751–1761

2. Hou X., Zhang X., Zou H., Guan M., Fu C., Wang W., Zhang Z., Geng Y., Chen Y. (2023) Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3 and ApoE4. Neuron 111: 1-16

3. Ni J., Ren Y., Su T., Zhou J., Fu C., Lu Y., Li D., Zhao J., Li Y., Zhang Y., Fang Y., Liu N., Geng Y., Chen Y. (2023) Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies. Mol. Psychiatry 28(2):931-945. (Cover)

4. Zhou J., Geng Y., Su T., Wang Q., Ren Y., Zhao J., Fu C., Weber M., Lin H., Kaminker., Liu N., Sheng M., Chen Y. (2022) NMDA receptor-dependent Prostaglandin-Endoperoxide Synthase 2 induction in neurons promotes glial proliferation during brain development and injury. Cell Rep. 38(13):110557

5. Ni J., Ren Y., Su T., Zhou J., Fu C., Lu Y., Li D., Zhao J., Li Y., Zhang Y., Fang Y., Liu N., Geng Y., Chen Y. (2022) Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies. Mol. Psychiatry (In press)

6. Deng X., Sun X., Yue W., Duan Y., Hu R., Zhang K., Ni J., Cui J., Wang Q., Chen Y., Li A., Fang Y. (2022) CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1. J. Cell Biol. 221:e202103022

7. Hanson J.E., Ma K., Elstrott J., Weber M., Saillet S., Khan A.S., Simms J., Liu B., Kim T.A., Yu G.Q., Chen Y., Wang T.M., Jiang Z., Liederer B.M., Deshmukh G., Solanoy H., Chan C., Sellers B.D., Volgraf M., Schwarz J.B., Hackos D.H., Weimer R.M., Sheng M., Gill T.M., Scearce-Levie K., Palop J.J. (2020) GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. Cell Rep. 30:381-396

8. Yang L., Ma Z., Wang H., Niu K., Cao Y., Sun L., Geng Y., Yang B., Gao F., Chen Z., Wu Z., Li Q., Shen Y., Zhang X., Jiang H., Chen Y., Liu R., Liu N., Zhang Y. (2019) Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker. Nat. Commun. 10:2191

9. Li C, Yan J, Tang D, Zhu J, Huang C, Sun Y, Hu R, Wang H, Fu C, Chen Y^#, Jiang H^#. (2020) GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats. Sci. Rep. 10:5265

10. Su T., Lu Y., Geng Y., Lu W., Chen Y. (2019) How could N-methyl-D- aspartate receptor antagonists lead to excitation instead of inhibition? Brain Sci. Adv. 4:73-98

11. Chen Y., Geng Y. (2017) Synaptic engineering: A new level of brain modulation. Brain Res. Bull. 129:23-29

12. Hackos D.H., Lupardus P.J., Grand T., Chen Y., Wang T.M., Reynen P., Gustafson A., Wallweber H.J., Volgraf M., Sellers B.D., Schwarz J.B., Paoletti P., Sheng M., Zhou Q., Hanson J.E.. (2016) Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function. Neuron. 89:983-99.

13. Chen Y., Wang Y., Ertürk A., Kallop D., Jiang Z., Weimer R.M., Kaminker J., Sheng M. (2014) Activity-induced Nr4a1 regulates spine density and distribution pattern of excitatory synapses in pyramidal neurons. Neuron. 83:431-43. (Recommended by F1000)

14. Chen Y., Wang Y., Sheng M. and Kaminker J. (2014) Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for Histone Deacetylase 4. J. Neurosci. 34:15327-39.

15. Nelson C.D., Kim M.J., Hsin H. Chen Y., Sheng M. (2013) Phosphorylation of Threonine-19 of PSD-95 by GSK-3beta is Required for PSD-95 Mobilization and Long-Term Depression. J. Neurosci. 33:12122-35.

16. Alagille D., Dacosta H., Chen Y., Hemstapat K., Rodriguez A., Baldwin R.M., Conn J.P., Tamagnan G.D. (2011) Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg. Med. Chem. Lett. 21:3243-7.

17. Ayala, J.E. *, Chen Y.*, Banko J.L., Sheffler D., Williams R., Telk A.N., Watson N.L., Xiang Z., Zhang Y., Jones P.J., Lindsley C.W., Olive M.F. and Conn P.J. (2009) mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology. 34:2057-71. (* contributed equally)

18. Chen Y. and Conn P.J. (2008) mGluR5 positive allosteric modulators. Drugs of the Future. 33:335

19. Chen Y., Goudet C., Pin J.P. and Conn P.J. (2008) CPPHA acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.  Mol. Pharmacol. 73:909-18

20. Chen Y., Nong Y., Goudet C., Hemstapat K., de Paulis T., Pin J.P. and Conn J.P. (2007) Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol. Pharmacol. 71:1389-98

21. Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ. (2006) A novel class of positive allosteric modulators of mGluR1 interact with a site distinct from that of negative allosteric modulators.  Mol. Pharmacol.  70:616-26

22. De Paulis T., Hemstapat K., Chen Y., Zhang Y., Saleh S., Alagille D., Baldwin R.M., Tamagnan G.D., Conn P.J. (2006) Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.  J. Med. Chem. 49:3332-44