Publications (Updated in Feb 2024):

1 Wei, J. et al. Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis. Signal Transduction and Targeted Therapy 8 (1), 451 (2023).

2 Li, Y. et al. Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ishemic brain injury. Proceedings of the National Academy of Sciences 120 (5), e2218091120 (2023).

3 Wu, Q. et al. Microglial dysfunction in neurodegenerative diseases via RIPK1 and ROS. Antioxidants 11 (11), 2201 (2022).

4 Shi, Y. et al. Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO). Nature Neuroscience 25, 317-329 (2022).

5 Li, W. et al. Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response. Cell Research, 1-17 (2022).

6 Xu, D. et al. Genetic Regulation of RIPK1 and Necroptosis. Annual Review of Genetics 55, 235-263 (2021).

7 Wang, H. et al. NEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation. Nature communications 12, 1-19 (2021).

8 Mifflin, L. et al. A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences 118, e2025102118 (2021).

9 Zou, C. et al. Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer’s Disease. Cell Reports 33, 108447 (2020).

10 Xu, D. et al. TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging. Cell 174, 1477-1491. e1419 (2018).

11 Ofengeim, D. et al. RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease. Proceedings of the National Academy of Sciences 114, E8788-E8797 (2017).

12 Ofengeim, D. et al. Single-cell RNA sequencing: unraveling the brain one cell at a time. Trends in molecular medicine 23, 563-576 (2017).

13 Zou, C. et al. Neuroinflammation impairs adaptive structural plasticity of dendritic spines in a preclinical model of Alzheimer’s disease. Acta neuropathologica 131, 235-246 (2016).

14 Zou, C. et al. Amyloid precursor protein maintains constitutive and adaptive plasticity of dendritic spines in adult brain by regulating D‐serine homeostasis. The EMBO journal 35, 2213-2222 (2016).

15 Zou, C. et al. Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer’s disease. Acta neuropathologica 129, 909-920 (2015).

16 Dorostkar, M. M. et al. Analyzing dendritic spine pathology in Alzheimer’s disease: problems and opportunities. Acta neuropathologica 130, 1-19 (2015).